| Title: | Genome-wide association study identifies 48 common genetic variants associated with handedness |
| Journal: | Nature Human Behaviour |
| Published: | 28 Sep 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32989287/ |
| DOI: | https://doi.org/10.1038/s41562-020-00956-y |
| URL: | https://repository.ubn.ru.nl//bitstream/handle/2066/224907/224907.pdf |
| Citations: | 109 (45 in last 2 years) as of 8 Aug 2024 |
Publication 9235
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Abstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.</p>
15 Keywords
- Adult
- Aged
- Female
- Functional Laterality
- Gene Frequency
- Genetic Loci
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Quantitative Trait, Heritable
- Sex Factors
118 Authors
- Gabriel Cuellar-Partida
- Joyce Y. Tung
- Nicholas Eriksson
- Eva Albrecht
- Fazil Aliev
- Ole A. Andreassen
- Inês Barroso
- Jacques S. Beckmann
- Marco P. Boks
- Dorret I. Boomsma
- Heather A. Boyd
- Monique M. B. Breteler
- Harry Campbell
- Daniel I. Chasman
- Lynn F. Cherkas
- Gail Davies
- Eco J. C. de Geus
- Ian J. Deary
- Panos Deloukas
- Danielle M. Dick
- David L. Duffy
- Johan G. Eriksson
- Tõnu Esko
- Bjarke Feenstra
- Frank Geller
- Christian Gieger
- Ina Giegling
- Scott D. Gordon
- Jiali Han
- Thomas F. Hansen
- Annette M. Hartmann
- Caroline Hayward
- Kauko Heikkilä
- Andrew A. Hicks
- Joel N. Hirschhorn
- Jouke-Jan Hottenga
- Jennifer E. Huffman
- Liang-Dar Hwang
- M. Arfan Ikram
- Jaakko Kaprio
- John P. Kemp
- Kay-Tee Khaw
- Norman Klopp
- Bettina Konte
- Zoltan Kutalik
- Jari Lahti
- Xin Li
- Ruth J. F. Loos
- Michelle Luciano
- Sigurdur H. Magnusson
- Massimo Mangino
- Pedro Marques-Vidal
- Nicholas G. Martin
- Wendy L. McArdle
- Mark I. McCarthy
- Carolina Medina-Gomez
- Mads Melbye
- Scott A. Melville
- Andres Metspalu
- Lili Milani
- Vincent Mooser
- Mari Nelis
- Dale R. Nyholt
- Kevin S. O'Connell
- Roel A. Ophoff
- Cameron Palmer
- Aarno Palotie
- Teemu Palviainen
- Guillaume Pare
- Lavinia Paternoster
- Leena Peltonen
- Brenda W. J. H. Penninx
- Ozren Polasek
- Peter P. Pramstaller
- Inga Prokopenko
- Katri Raikkonen
- Samuli Ripatti
- Fernando Rivadeneira
- Igor Rudan
- Dan Rujescu
- Johannes H. Smit
- George Davey Smith
- Jordan W. Smoller
- Nicole Soranzo
- Tim D. Spector
- Beate St Pourcain
- John M. Starr
- Hreinn Stefánsson
- Stacy Steinberg
- Maris Teder-Laving
- Gudmar Thorleifsson
- Kári Stefánsson
- Nicholas J. Timpson
- André G. Uitterlinden
- Cornelia M. van Duijn
- Frank J. A. van Rooij
- Jaqueline M. Vink
- Peter Vollenweider
- Eero Vuoksimaa
- Gérard Waeber
- Nicholas J. Wareham
- Nicole Warrington
- Dawn Waterworth
- Thomas Werge
- H.-Erich Wichmann
- Elisabeth Widen
- Gonneke Willemsen
- Alan F. Wright
- Margaret J. Wright
- Mousheng Xu
- Jing Hua Zhao
- Peter Kraft
- David A. Hinds
- Cecilia M. Lindgren
- Reedik Mägi
- Benjamin M. Neale
- David M. Evans
- Sarah E. Medland
1 Application
| Application ID | Title |
|---|---|
| 12703 | Investigating the Genetic Architecture Underlying the Developmental Origins of Health and Disease |
Enabling scientific discoveries that improve human health