Title: | Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank |
Journal: | Nature Genetics |
Published: | 10 Jan 2024 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38200128/ |
DOI: | https://doi.org/10.1038/s41588-023-01625-2 |
Title: | Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank |
Journal: | Nature Genetics |
Published: | 10 Jan 2024 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38200128/ |
DOI: | https://doi.org/10.1038/s41588-023-01625-2 |
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) is a surrogate marker of IR. We conducted a genome-wide association study of the TG:HDL-C ratio in 402,398 Europeans within the UK Biobank. We identified 369 independent SNPs, of which 114 had a false discovery rate-adjusted P value < 0.05 in other genome-wide studies of IR making them high-confidence IR-associated loci. Seventy-two of these 114 loci have not been previously associated with IR. These 114 loci cluster into five groups upon phenome-wide analysis and are enriched for candidate genes important in insulin signaling, adipocyte physiology and protein metabolism. We created a polygenic-risk score from the high-confidence IR-associated loci using 51,550 European individuals in the Michigan Genomics Initiative. We identified associations with diabetes, hyperglyceridemia, hypertension, nonalcoholic fatty liver disease and ischemic heart disease. Collectively, this study provides insight into the genes, pathways, tissues and subtypes critical in IR.</p>
Application ID | Title |
---|---|
18120 | Identifying causes of obesity and liver disease using population genetics |
Enabling scientific discoveries that improve human health