| Title: | Exome-wide association study of plasma lipids in >300,000 individuals |
| Journal: | Nature Genetics |
| Published: | 30 Oct 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29083408/ |
| DOI: | https://doi.org/10.1038/ng.3977 |
| URL: | http://hdl.handle.net/1887/95201 |
| Citations: | 489 (80 in last 2 years) as of 8 Aug 2024 |
Publication 8494
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Abstract
Exome-wide genetic analysis on >300,000 individuals identifies associations with plasma lipid traits. Loci significantly associated with cholesterol and triglycerides are examined together to determine the effects of alleles on type 2 diabetes and coronary artery disease risk.</p>
12 Keywords
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Exome
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans
- Lipids
- Macular Degeneration
- Phenotype
- Risk Factors
227 Authors
- Dajiang J Liu
- Gina M Peloso
- Haojie Yu
- Adam S Butterworth
- Xiao Wang
- Anubha Mahajan
- Danish Saleheen
- Connor Emdin
- Dewan Alam
- Alexessander Couto Alves
- Philippe Amouyel
- Emanuele Di Angelantonio
- Dominique Arveiler
- Themistocles L Assimes
- Paul L Auer
- Usman Baber
- Christie M Ballantyne
- Lia E Bang
- Marianne Benn
- Joshua C Bis
- Michael Boehnke
- Eric Boerwinkle
- Jette Bork-Jensen
- Erwin P Bottinger
- Ivan Brandslund
- Morris Brown
- Fabio Busonero
- Mark J Caulfield
- John C Chambers
- Daniel I Chasman
- Y Eugene Chen
- Yii-Der Ida Chen
- Rajiv Chowdhury
- Cramer Christensen
- Audrey Y Chu
- John M Connell
- Francesco Cucca
- L Adrienne Cupples
- Scott M Damrauer
- Gail Davies
- Ian J Deary
- George Dedoussis
- Joshua C Denny
- Anna Dominiczak
- Marie-Pierre Dubé
- Tapani Ebeling
- Gudny Eiriksdottir
- Tõnu Esko
- Aliki-Eleni Farmaki
- Mary F Feitosa
- Marco Ferrario
- Jean Ferrieres
- Ian Ford
- Myriam Fornage
- Paul W Franks
- Timothy M Frayling
- Ruth Frikke-Schmidt
- Lars G Fritsche
- Philippe Frossard
- Valentin Fuster
- Santhi K Ganesh
- Wei Gao
- Melissa E Garcia
- Christian Gieger
- Franco Giulianini
- Mark O Goodarzi
- Harald Grallert
- Niels Grarup
- Leif Groop
- Megan L Grove
- Vilmundur Gudnason
- Torben Hansen
- Tamara B Harris
- Caroline Hayward
- Joel N Hirschhorn
- Oddgeir L Holmen
- Jennifer Huffman
- Yong Huo
- Kristian Hveem
- Sehrish Jabeen
- Anne U Jackson
- Johanna Jakobsdottir
- Marjo-Riitta Jarvelin
- Gorm B Jensen
- Marit E Jørgensen
- J Wouter Jukema
- Johanne M Justesen
- Pia R Kamstrup
- Stavroula Kanoni
- Fredrik Karpe
- Frank Kee
- Amit V Khera
- Derek Klarin
- Heikki A Koistinen
- Jaspal S Kooner
- Charles Kooperberg
- Kari Kuulasmaa
- Johanna Kuusisto
- Markku Laakso
- Timo Lakka
- Claudia Langenberg
- Anne Langsted
- Lenore J Launer
- Torsten Lauritzen
- David C M Liewald
- Li An Lin
- Allan Linneberg
- Ruth J F Loos
- Yingchang Lu
- Xiangfeng Lu
- Reedik Mägi
- Anders Malarstig
- Ani Manichaikul
- Alisa K Manning
- Pekka Mäntyselkä
- Eirini Marouli
- Nicholas G D Masca
- Andrea Maschio
- James B Meigs
- Olle Melander
- Andres Metspalu
- Andrew P Morris
- Alanna C Morrison
- Antonella Mulas
- Martina Müller-Nurasyid
- Patricia B Munroe
- Matt J Neville
- Jonas B Nielsen
- Sune F Nielsen
- Børge G Nordestgaard
- Jose M Ordovas
- Roxana Mehran
- Christoper J O'Donnell
- Marju Orho-Melander
- Cliona M Molony
- Pieter Muntendam
- Sandosh Padmanabhan
- Colin N A Palmer
- Dorota Pasko
- Aniruddh P Patel
- Oluf Pedersen
- Markus Perola
- Annette Peters
- Charlotta Pisinger
- Giorgio Pistis
- Ozren Polasek
- Neil Poulter
- Bruce M Psaty
- Daniel J Rader
- Asif Rasheed
- Rainer Rauramaa
- Dermot F Reilly
- Alex P Reiner
- Frida Renström
- Stephen S Rich
- Paul M Ridker
- John D Rioux
- Neil R Robertson
- Dan M Roden
- Jerome I Rotter
- Igor Rudan
- Veikko Salomaa
- Nilesh J Samani
- Serena Sanna
- Naveed Sattar
- Ellen M Schmidt
- Robert A Scott
- Peter Sever
- Raquel S Sevilla
- Christian M Shaffer
- Xueling Sim
- Suthesh Sivapalaratnam
- Kerrin S Small
- Albert V Smith
- Blair H Smith
- Sangeetha Somayajula
- Lorraine Southam
- Timothy D Spector
- Elizabeth K Speliotes
- John M Starr
- Kathleen E Stirrups
- Nathan Stitziel
- Konstantin Strauch
- Heather M Stringham
- Praveen Surendran
- Hayato Tada
- Alan R Tall
- Hua Tang
- Jean-Claude Tardif
- Kent D Taylor
- Stella Trompet
- Philip S Tsao
- Jaakko Tuomilehto
- Anne Tybjaerg-Hansen
- Natalie R van Zuydam
- Anette Varbo
- Tibor V Varga
- Jarmo Virtamo
- Melanie Waldenberger
- Nan Wang
- Nick J Wareham
- Helen R Warren
- Peter E Weeke
- Joshua Weinstock
- Jennifer Wessel
- James G Wilson
- Peter W F Wilson
- Ming Xu
- Hanieh Yaghootkar
- Robin Young
- Eleftheria Zeggini
- He Zhang
- Neil S Zheng
- Weihua Zhang
- Yan Zhang
- Wei Zhou
- Yanhua Zhou
- Magdalena Zoledziewska
- Joanna M M Howson
- John Danesh
- Mark I McCarthy
- Chad A Cowan
- Goncalo Abecasis
- Panos Deloukas
- Kiran Musunuru
- Cristen J Willer
- Sekar Kathiresan
1 Application
| Application ID | Title |
|---|---|
| 7089 | Exome Sequencing of All Premature Coronary Artery Disease Participants in UK Biobank |
Enabling scientific discoveries that improve human health