| Title: | Family History of AD/Dementia, Polygenic Risk Score for AD, and Parkinson's Disease |
| Journal: | Movement Disorders Clinical Practice |
| Published: | 11 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38094649/ |
| DOI: | https://doi.org/10.1002/mdc3.13919 |
| URL: | https://pmc.ncbi.nlm.nih.gov/articles/PMC10715357/pdf/MDC3-10-1787.pdf |
Publication 8349
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Abstract
Background: Co-occurrence of Alzheimer's disease (AD) and Parkinson's disease (PD) has been observed. However, there is limited knowledge on how family history of AD is associated with PD.</p>
Objectives: To prospectively examine the associations of family history of AD/dementia and polygenic risk score for AD (AD-PRS) with PD risk.</p>
Methods: The study included 477,190 participants from UK Biobank who were free of PD at baseline (2006-2010) and had complete data on the studied exposure variables, family history of AD and AD-PRS. Cox proportional hazards model was used to examine the hazard ratios (HRs) and their 95% confidence intervals (CIs) of family history of AD/dementia and AD-PRS for PD risk. We also conducted mediation analysis to examine the proportion of the association between family history of AD/dementia and PD risk that could be mediated by AD-PRS.</p>
Results: During a median follow-up of 12.5 years, we identified 2550 incidences of PD. Family history of AD/dementia (adjusted HR = 1.21; 95% CI 1.09-1.35) and AD-PRS (adjusted HR = 1.10 per 1 unit increment; 95% CI 1.05-1.14) were associated with PD risk, after adjustment for age, sex, lifestyle factors, and other potential confounders. The association between family history of AD/dementia and PD risk was mediated by 13.1% by the AD-PRS. As expected, we observed significant associations of family history of AD/dementia and AD-PRS with risks of dementia and AD (P < 0.001 for all).</p>
Conclusions: Family history of AD/dementia appeared to be associated with PD risk, and this association could be mediated partially by AD-related genetic factors.</p>
9 Authors
- Xinming Xu
- Yaqi Li
- Jian Wang
- Yaying Cao
- Chengwu Feng
- Yi Guo
- Geng Zong
- Liang Sun
- Xiang Gao
1 Application
| Application ID | Title |
|---|---|
| 96083 | Associations of diet and metabolic profile with risk of cardiometabolic disease and neurodegenerative disease |
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