| Title: | Association of serum levels of calcium phosphate and vitamin D with risk of developing aortic stenosis: the UK Biobank cohort. |
| Journal: | European Journal of Preventive Cardiology |
| Published: | 1 Feb 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35104862/ |
| DOI: | https://doi.org/10.1093/eurjpc/zwac016 |
Publication 7593
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
AIMS: To investigate associations of serum calcium, phosphate and vitamin D levels with the risk of developing aortic stenosis. METHODS AND RESULTS: We included 296,415 participants who were free of prior diagnosis of any valvular heart disease from the UK Biobank. Serum levels of phosphate, calcium and vitamin D were measured. Incidental of AS was determined by the records of hospital data. Cox regression was used to exam the association of serum mineral levels with incidental aortic stenosis after adjustment for potential confounders. The mean age was 56.4 years (SD 8.14) and 53.3% of participants were women. During an average follow-up of 8.1 years, 1232 individuals developed aortic stenosis. After adjustment, each 0.5-unit increase in serum phosphate level was associated with a 50% increase of aortic stenosis risk (HR 1.50, 95%CI 1.26 to 1.80). We observed no association of serum calcium and vitamin D levels with aortic stenosis. CONCLUSION: Increased serum phosphate level, but not calcium or vitamin D, was associated with a higher risk of incident aortic stenosis, this association did not differed substantially between patients with and without decreased kidney function. This finding implied that phosphate may be a potential interventional target for aortic stenosis.6 Authors
- Congying Xia
- Wenhua Lei
- Yao Hu
- Huazhen Yang
- Xiaoxi Zeng
- Mao Chen
Enabling scientific discoveries that improve human health