| Title: | Association between household size and COVID-19: A UK Biobank observational study |
| Journal: | Journal of the Royal Society of Medicine |
| Published: | 4 Feb 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35118908/ |
| DOI: | https://doi.org/10.1177/01410768211073923 |
| URL: | https://journals.sagepub.com/doi/pdf/10.1177/01410768211073923 |
Publication 7592
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Abstract
OBJECTIVE: To assess the association between household size and risk of non-severe or severe COVID-19. DESIGN: A longitudinal observational study. SETTING: This study utilised UK Biobank linked to national SARS-CoV-2 laboratory test data. PARTICIPANTS: 401,910 individuals with available data on household size in UK Biobank. MAIN OUTCOME MEASURES: Household size was categorised as single occupancy, two-person households and households of three or more. Severe COVID-19 was defined as a positive SARS-CoV-2 test on hospital admission or death with COVID-19 recorded as the underlying cause; and non-severe COVID-19 as a positive test from a community setting. Logistic regression models were fitted to assess associations, adjusting for potential confounders. RESULTS: Of 401,910 individuals, 3612 (1%) were identified as having suffered from a severe COVID-19 infection and 11,264 (2.8%) from a non-severe infection, between 16 March 2020 and 16 March 2021. Overall, the odds of severe COVID-19 was significantly higher among individuals living alone (adjusted odds ratio: 1.24 [95% confidence interval: 1.14 to 1.36], or living in a household of three or more individuals (adjusted odds ratio: 1.28 [1.17 to 1.39], when compared to individuals living in a household of two. For non-severe COVID-19 infection, individuals living in a single-occupancy household had lower odds compared to those living in a household of two (adjusted odds ratio: 0.88 [0.82 to 0.93]. CONCLUSIONS: Odds of severe or non-severe COVID-19 infection were associated with household size. Increasing understanding of why certain households are more at risk is important for limiting spread of the infection.12 Authors
- Clare L Gillies
- Alex V Rowlands
- Cameron Razieh
- Vahé Nafilyan
- Yogini Chudasama
- Nazrul Islam
- Francesco Zaccardi
- Daniel Ayoubkhani
- Claire Lawson
- Melanie J Davies
- Tom Yates
- Kamlesh Khunti
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