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Abstract
Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.
11 Authors
Kenichi Yamamoto
Kyuto Sonehara
Shinichi Namba
Takahiro Konuma
Hironori Masuko
Satoru Miyawaki
Yoichiro Kamatani
Nobuyuki Hizawa
Keiichi Ozono
Loic Yengo
Yukinori Okada
Enabling scientific discoveries that improve human health