| Title: | Cardiac aging synthesis from cross-sectional data with conditional generative adversarial networks |
| Journal: | Frontiers in Cardiovascular Medicine |
| Published: | 23 Sep 2022 |
| DOI: | https://doi.org/10.3389/fcvm.2022.983091 |
| URL: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.983091/pdf |
Publication 7560
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Age has important implications for health, and understanding how age manifests in the human body is the first step for a potential intervention. This becomes especially important for cardiac health, since age is the main risk factor for development of cardiovascular disease. Data-driven modeling of age progression has been conducted successfully in diverse applications such as face or brain aging. While longitudinal data is the preferred option for training deep learning models, collecting such a dataset is usually very costly, especially in medical imaging. In this work, a conditional generative adversarial network is proposed to synthesize older and younger versions of a heart scan by using only cross-sectional data. We train our model with more than 14,000 different scans from the UK Biobank. The induced modifications focused mainly on the interventricular septum and the aorta, which is consistent with the existing literature in cardiac aging. We evaluate the results by measuring image quality, the mean absolute error for predicted age using a pre-trained regressor, and demonstrate the application of synthetic data for counter-balancing biased datasets. The results suggest that the proposed approach is able to model realistic changes in the heart using only cross-sectional data and that these data can be used to correct age bias in a dataset.9 Authors
- Víctor M. Campello
- Tian Xia
- Xiao Liu
- Pedro Sanchez
- Carlos Martín-Isla
- Steffen E. Petersen
- Santi Seguí
- Sotirios A. Tsaftaris
- Karim Lekadir
Enabling scientific discoveries that improve human health