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Abstract
Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease. They identify a low-frequency missense variant in ADCY7 that doubles risk of ulcerative colitis and detect a burden of very rare, damaging missense variants in known Crohn's disease risk genes.
30 Authors
Yang Luo
Katrina M de Lange
Luke Jostins
Loukas Moutsianas
Joshua Randall
Nicholas A Kennedy
Christopher A Lamb
Shane McCarthy
Tariq Ahmad
Cathryn Edwards
Eva Goncalves Serra
Ailsa Hart
Chris Hawkey
John C Mansfield
Craig Mowat
William G Newman
Sam Nichols
Martin Pollard
Jack Satsangi
Alison Simmons
Mark Tremelling
Holm Uhlig
David C Wilson
James C Lee
Natalie J Prescott
Charlie W Lees
Christopher G Mathew
Miles Parkes
Jeffrey C Barrett
Carl A Anderson
Enabling scientific discoveries that improve human health