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Abstract
John Perry and colleagues identify genetic variants at 19 genomic regions associated with mosaic loss of the Y chromosome (mLOY) in blood. They further highlight a shared genetic architecture between mLOY and cancer susceptibility, and infer a causal effect of smoking on mLOY.
19 Authors
Daniel J Wright
Felix R Day
Nicola D Kerrison
Florian Zink
Alexia Cardona
Patrick Sulem
Deborah J Thompson
Svanhvit Sigurjonsdottir
Daniel F Gudbjartsson
Agnar Helgason
J Ross Chapman
Steve P Jackson
Claudia Langenberg
Nicholas J Wareham
Robert A Scott
Unnur Thorsteindottir
Ken K Ong
Kari Stefansson
John R B Perry
Enabling scientific discoveries that improve human health