| Title: | Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19 |
| Journal: | Nature Genetics |
| Published: | 13 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35027740/ |
| DOI: | https://doi.org/10.1038/s41588-021-00996-8 |
| URL: | https://www.nature.com/articles/s41588-021-00996-8.pdf |
Publication 7430
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Abstract
The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.13 Authors
- Jennifer E. Huffman
- Guillaume Butler-Laporte
- Atlas Khan
- Erola Pairo-Castineira
- Theodore G. Drivas
- Gina M. Peloso
- Tomoko Nakanishi
- Andrea Ganna
- Anurag Verma
- J. Kenneth Baillie
- Krzysztof Kiryluk
- J. Brent Richards
- Hugo Zeberg
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