| Title: | New genetic loci associated with the risk of clonal hematopoiesis |
| Journal: | Nature Genetics |
| Published: | 18 Jul 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35851190/ |
| DOI: | https://doi.org/10.1038/s41588-022-01125-9 |
| URL: | https://www.nature.com/articles/s41588-022-01125-9.pdf |
Publication 7409
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Abstract
Genetic and phenotypic analyses of data from over 400,000 participants in the UK Biobank identified 10 new loci associated with the development of clonal hematopoiesis and implicated DNA damage, oncogene signaling, telomere maintenance and blood cell homing in its pathogenesis. These findings can help to decipher the pathogenesis of clonal hematopoiesis and develop therapeutic approaches.Enabling scientific discoveries that improve human health