| Title: | Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples. |
| Journal: | Human Molecular Genetics |
| Published: | 6 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35932451/ |
| DOI: | https://doi.org/10.1093/hmg/ddac186 |
Publication 7405
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Abstract
Participant overlap can induce overfitting bias into Mendelian randomization (MR) and polygenic risk score (PRS) studies. Here, we evaluated a block jackknife resampling framework for genome-wide association studies (GWAS) and PRS construction to mitigate overfitting bias in MR analyses and implemented this study design in a causal inference setting using data from the UK Biobank.5 Authors
- Si Fang
- Gibran Hemani
- Tom G Richardson
- Tom R Gaunt
- George Davey Smith
Enabling scientific discoveries that improve human health