| Title: | Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes. |
| Journal: | Diabetes Care |
| Published: | 9 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35944243/ |
| DOI: | https://doi.org/10.2337/dc22-0177 |
| URL: | https://diabetesjournals.figshare.com/articles/figure/Microvascular_burden_and_incident_heart_failure_among_middle-aged_and_older_adults_with_type_1_or_type_2_diabetes/20360028/1/files/36392511.pdf |
Publication 7367
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
OBJECTIVE: To examine the association between microvascular disease (MVD) and risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM).RESEARCH DESIGN AND METHODS: We included 1,713 and 28,624 participants with T1DM and T2DM, respectively, from the UK Biobank who were free of HF during enrollment. MVD burden reflected by the presence of retinopathy, peripheral neuropathy, and chronic kidney disease (CKD) at baseline was prospectively evaluated for the association with incidence of HF. Hazard ratios (HRs) and 95% CIs of HF were estimated by Cox regression models adjusted for multiple traditional risk factors.
RESULTS: There were 145 and 2,515 incident cases of HF recorded among participants with T1DM and T2DM, respectively, during a median follow-up of 11.5 years. The association between the number of MVD and HF was stronger among participants with T1DM than among those with T2DM (P for interaction <0.001). Compared with participants with no MVD, those with all three MVD had an adjusted HR (95% CI) of 11.37 (5.62, 22.99) in T1DM and 3.66 (2.74, 4.88) in T2DM. In T1DM, HRs (CIs) were 2.69 (1.75, 4.14) for retinopathy, 2.11 (1.38, 3.23) for peripheral neuropathy, and 2.21 (1.53, 3.18) for CKD. The corresponding estimates in T2DM were 1.24 (1.13, 1.36), 1.63 (1.36, 1.96), and 1.73 (1.59, 1.89), respectively.
CONCLUSIONS: While a heavier burden of MVD was associated with excess risk of HF both in T1DM and T2DM, the association was evidently more pronounced in T1DM.
6 Authors
- Fu-Rong Li
- Daniel Nyarko Hukportie
- Jing Yang
- Huan-Huan Yang
- Guo-Chong Chen
- Xian-Bo Wu
Enabling scientific discoveries that improve human health