| Title: | Chronic pain and COVID-19 hospitalisation and mortality: a UK Biobank cohort study. |
| Journal: | Pain |
| Published: | 22 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35452027/ |
| DOI: | https://doi.org/10.1097/j.pain.0000000000002663 |
| URL: | https://journals.lww.com/pain/Fulltext/9900/Chronic_pain_and_COVID_19_hospitalisation_and.71.aspx |
Publication 7145
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Abstract
ABSTRACT: The risk of COVID-19 in those with chronic pain is unknown. We investigated whether self-reported chronic pain was associated with COVID-19 hospitalisation or mortality. UK Biobank recruited 502,624 participants aged 37 to 73 years between 2006 and 2010. Baseline exposure data, including chronic pain (>3 months, in at least 1 of 7 prespecified body sites) and chronic widespread pain (>3 months, all over body), were linked to COVID-19 hospitalisations or mortality. Univariable or multivariable Poisson regression analyses were performed on the association between chronic pain and COVID-19 hospitalisation and Cox regression analyses of the associations with COVID-19 mortality. Multivariable analyses adjusted incrementally for sociodemographic confounders, then lifestyle risk factors, and finally long-term condition count. Of 441,403 UK Biobank participants with complete data, 3180 (0.7%) were hospitalised for COVID-19 and 1040 (0.2%) died from COVID-19. Chronic pain was associated with hospital admission for COVID-19 even after adjustment for all covariates (incidence rate ratio 1.16; 95% confidence interval [CI] 1.08-1.24; P < 0.001), as was chronic widespread pain (incidence rate ratio 1.33; 95% CI 1.06-1.66; P = 0.012). There was clear evidence of a dose-response relationship with number of pain sites (fully adjusted global P-value < 0.001). After adjustment for all covariates, there was no association between chronic pain (HR 1.01; 95% CI 0.89-1.15; P = 0.834) but attenuated association with chronic widespread pain (HR 1.50, 95% CI 1.04-2.16, P-value = 0.032) and COVID-19 mortality. Chronic pain is associated with higher risk of hospitalisation for COVID-19, but the association with mortality is unclear. Future research is required to investigate these findings further and determine whether pain is associated with long COVID.10 Authors
- Claire E Hastie
- Hamish M E Foster
- Bhautesh D Jani
- Catherine A O'Donnell
- Frederick K Ho
- Jill P Pell
- Naveed Sattar
- Srinivasa V Katikireddi
- Frances S Mair
- Barbara I Nicholl
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