| Title: | Adherence to a Healthy Sleep Pattern and Incidence of Cardiometabolic Multimorbidity Among Hypertensive Patients: A Prospective Study of UK Biobank. |
| Journal: | Sleep |
| Published: | 23 Jun 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35738866/ |
| DOI: | https://doi.org/10.1093/sleep/zsac141 |
| URL: | https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsac141/45014958/zsac141.pdf |
Publication 7103
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Abstract
STUDY OBJECTIVES: To investigate whether a healthy sleep pattern would reduce the risk of cardiometabolic multimorbidity (CMM) among hypertensives.METHODS: This is a prospective cohort analysis from the UK Biobank. A total of 69,524 hypertensives without a history of diabetes mellitus, coronary heart disease, or stroke at baseline were enrolled. Five dimensions of healthy sleep at baseline including early chronotype, sleep 7-8 hours/day, free of insomnia, no snoring, and no frequent excessive daytime sleepiness were used to generate a healthy sleep score ranging from 0 to 5 (one point was given for each dimension of healthy sleep). A higher score indicated a healthier sleep pattern. We set five groups corresponding to the healthy sleep score of 5, 4, 3, 2, 0-1, respectively. The primary outcome was the incidence of overall CMM among enrolled hypertensives. We assessed the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) by Fine-Gray sub-distribution hazard models.
RESULTS: We found the full-adjusted HR (95% CI) for overall CMM was 0.93 (0.91-0.95) for a 1-point increase in the healthy sleep score. Compared to hypertensives with a healthy sleep score of 0-1, those with a score of 5 had a 27% lower risk of overall CMM, and 37%, 23%, and 20% lower risks of diabetes mellitus, coronary heart disease, and stroke, respectively, after adjusting for sociodemographic characteristic, lifestyle, and clinical factors.
CONCLUSION: Our results indicated that a healthy sleep pattern was associated with lower risks of CMM outcomes among hypertensives.
7 Authors
- Lingfang He
- Tianqi Ma
- Jinchen Li
- Yi Luo
- Guogang Zhang
- Xunjie Cheng
- Yongping Bai
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