| Title: | Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants |
| Journal: | European Heart Journal |
| Published: | 18 Dec 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31848595/ |
| DOI: | https://doi.org/10.1093/eurheartj/ehz849 |
| URL: | https://academic.oup.com/eurheartj/article-pdf/41/11/1182/32906643/ehz849.pdf |
| Citations: | 349 (193 in last 2 years) as of 8 Aug 2024 |
Publication 5754
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
AIMS: To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD).</p>
METHODS AND RESULTS: This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7-8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0-1, participants with a score of 5 had a 35% (19-48%), 34% (22-44%), and 34% (25-42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke.</p>
CONCLUSION: In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk.</p>
9 Keywords
- Biological Specimen Banks
- Cardiovascular Diseases
- Genetic Predisposition to Disease
- Humans
- Incidence
- Prospective Studies
- Risk Factors
- Sleep
- United Kingdom
7 Authors
- Mengyu Fan
- Dianjianyi Sun
- Tao Zhou
- Yoriko Heianza
- Jun Lv
- Liming Li
- Lu Qi
Enabling scientific discoveries that improve human health