| Title: | Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK Biobank |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 20 Aug 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31450492/ |
| DOI: | https://doi.org/10.3233/jad-181132 |
Publication 5547
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Abstract
BACKGROUND: Apolipoprotein E (APOE) genotype affects the risk of Alzheimer's disease (AD) with inconclusive evidence on the opportunity to mitigate related adverse effects by lifestyle changes.</p>
OBJECTIVE: To examine the individual and interactive associations of APOE and objectively-measured physical activity (PA) and sedentary activity with cognitive decline.</p>
METHODS: We used data from middle-aged and older UK Biobank participants with repeat tests on visuospatial memory (n = 52,767) and fluid intelligence (n = 19,713), and who also took part in the accelerometer sub-study. PA and sedentary activity were assessed by a wrist-worn accelerometer over a seven-day period. Cognitive decline was defined as >1 standard deviation (SD) reduction in memory or fluid intelligence score, and the mean follow up from baseline was 5.8 years.</p>
RESULTS: There was an age dependent association between APOEɛ4 genotype and memory decline (page-interaction = 0.01), with the association only seen in participants who were >65 years (OR 1.33, 95% CI 1.11 to 1.24; for <65 years OR 1.06, 95% CI 0.99 to 1.14). The OR for the APOEɛ4 association with fluid intelligence decline was 1.11 (95% CI 0.99 to 1.24), and there was no evidence for age interaction (page-interaction = 0.99). High PA and low sedentary activity were associated with reduced mean memory decline (p < 0.02 for both). There was no interaction between PA or sedentary activity with APOEɛ4 regarding either of the cognitive decline measures (p > 0.63 for all).</p>
CONCLUSION: This large-scale study using objectively measured PA did not find differential effects of PA on cognitive decline based on APOE genotype.</p>
18 Keywords
- Adult
- Age Factors
- Aged
- Apolipoproteins E
- Biological Specimen Banks
- Cognitive Dysfunction
- Exercise
- Female
- Gene-Environment Interaction
- Genotype
- Humans
- Intelligence
- Male
- Memory
- Middle Aged
- Neuropsychological Tests
- Sedentary Behavior
- United Kingdom
4 Authors
- Stephanie Folley
- Ang Zhou
- David J. Llewellyn
- Elina Hyppönen
1 Application
| Application ID | Title |
|---|---|
| 10171 | Nutritional and lifestyle influences on neurocognitive and mental health: genetic epidemiological study on causal effects, mediating pathways and gene-environment interaction |
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