| Title: | Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers. |
| Journal: | The American Journal of Gastroenterology |
| Published: | 31 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32868629/ |
| DOI: | https://doi.org/10.14309/ajg.0000000000000833 |
| URL: | https://nottingham-repository.worktribe.com/preview/4709736/AJG-20-0154_R1.pdf |
Publication 5490
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Abstract
INTRODUCTION: Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk.</p>
METHODS: We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with equivalent alcohol exposure but no evidence of liver disease, 73.6% male). Information confirming or excluding cirrhosis, and on alcohol intake and other potential risk factors, was obtained from clinical records and by interview. Case-control differences in risk factors discovered in the GenomALC participants were validated using similar data from 407 cases and 6,573 controls from UK Biobank.</p>
RESULTS: The GenomALC case and control groups reported similar lifetime alcohol intake (1,374 vs 1,412 kg). Cases had a higher prevalence of diabetes (20.5% (262/1,288) vs 6.5% (48/734), P = 2.27 × 10-18) and higher premorbid body mass index (26.37 ± 0.16 kg/m2) than controls (24.44 ± 0.18 kg/m2, P = 5.77 × 10-15). Controls were significantly more likely to have been wine drinkers, coffee drinkers, smokers, and cannabis users than cases. Cases reported a higher proportion of parents who died of liver disease than controls (odds ratio 2.25 95% confidence interval 1.55-3.26). Data from UK Biobank confirmed these findings for diabetes, body mass index, proportion of alcohol as wine, and coffee consumption.</p>
DISCUSSION: If these relationships are causal, measures such as weight loss, intensive treatment of diabetes or prediabetic states, and coffee consumption should reduce the risk of alcohol-related cirrhosis.</p>
24 Keywords
- Alcohol Drinking
- Alcoholic Beverages
- Australia
- Case-Control Studies
- Coffee
- Diabetes Mellitus
- Female
- France
- Germany
- Humans
- Liver Cirrhosis, Alcoholic
- Logistic Models
- Male
- Marijuana Use
- Medical History Taking
- Middle Aged
- Obesity
- Risk Factors
- Smoking
- Switzerland
- Tea
- United Kingdom
- United States
- Wine
28 Authors
- John B Whitfield
- Steven Masson
- Suthat Liangpunsakul
- Sebastian Mueller
- Guruprasad P Aithal
- Florian Eyer
- Dermot Gleeson
- Andrew Thompson
- Felix Stickel
- Michael Soyka
- Beat Muellhaupt
- Ann K Daly
- Heather J Cordell
- Tatiana Foroud
- Lawrence Lumeng
- Munir Pirmohamed
- Bertrand Nalpas
- Jean-Marc Jacquet
- Romain Moirand
- Pierre Nahon
- Sylvie Naveau
- Pascal Perney
- Paul S Haber
- Helmut K Seitz
- Christopher P Day
- Philippe Mathurin
- Timothy R Morgan
- Devanshi Seth
Enabling scientific discoveries that improve human health