| Title: | Leisure-time physical activity and life expectancy in people with cardiometabolic multimorbidity and depression |
| Journal: | Journal of Internal Medicine |
| Published: | 6 Nov 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31602698/ |
| DOI: | https://doi.org/10.1111/joim.12987 |
Publication 5311
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Abstract
BACKGROUND: Whether and to what extent leisure-time physical activity at the recommended levels of 150-min moderate activity is associated with survival in people with cardiometabolic multimorbidity and depression is unknown.</p>
METHODS: UK Biobank participants were classified into groups: (i) no disease; (ii) diabetes; (iii) cardiovascular disease (CVD); (iv) depression; (v) diabetes and CVD; (vi) diabetes and depression; (vii) CVD and depression; (viii) diabetes, CVD and depression. Leisure-time physical activity was categorized as active (meeting recommendations) or inactive. Survival models were applied to estimate life expectancy.</p>
RESULTS: A total of 480 940 participants were included (median age, 58 years; 46% men; 95% white), of whom 74% with cardiometabolic multimorbidity and depression were inactive. During a mean follow-up of 7 years, 11 006 deaths occurred. At age of 45 years, being physically active was associated with 2.34 (95% confidence interval: 0.93, 3.54) additional years of life compared with being inactive in participants with diabetes; corresponding estimates were 2.28 (1.40, 3.16) for CVD; 2.15 (0.05, 4.26) for diabetes and CVD; and 1.58 (1.27, 1.89) for no disease. Participants with a combination of diabetes, CVD and depression, being active was associated with 6.81 (-1.50, 15.31) additional years compared with being inactive; corresponding estimates were 3.07 (-2.46, 8.59) for diabetes and depression; 2.34 (-1.24, 5.91) for CVD and depression; and 0.80 (-0.46, 2.05) for depression. A similar pattern was found at 65 years.</p>
CONCLUSIONS: Meeting the recommended level of physical activity was associated with a longer life expectancy in people with cardiometabolic multimorbidity but not in those with depression.</p>
13 Keywords
- Aged
- Cardiovascular Diseases
- Depression
- Diabetes Mellitus
- Exercise
- Female
- Humans
- Leisure Activities
- Life Expectancy
- Male
- Middle Aged
- Multimorbidity
- United Kingdom
8 Authors
- Y. V. Chudasama
- F. Zaccardi
- C. L. Gillies
- N. N. Dhalwani
- T. Yates
- A. V. Rowlands
- M. J Davies
- K. Khunti
1 Application
| Application ID | Title |
|---|---|
| 14146 | Multimorbidity prevalence, patterns and associated factors: Analysis of the UK Biobank |
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