| Title: | Large-scale whole-exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder |
| Journal: | CNS Neuroscience & Therapeutics |
| Published: | 11 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34633764/ |
| DOI: | https://doi.org/10.1111/cns.13733 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.13733 |
| Citations: | 8 (6 in last 2 years) as of 8 Aug 2024 |
Publication 5310
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the pathophysiology of MDD.11 Keywords
- Depressive Disorder, Major
- Exome Sequencing
- Female
- Forkhead Transcription Factors
- Genetic Predisposition to Disease
- Genetic Testing
- Genome-Wide Association Study
- Humans
- Male
- Polymorphism, Single Nucleotide
- Sphingolipids
9 Authors
- Wei Zhou
- Luan Chen
- Bixuan Jiang
- Yidan Sun
- Mo Li
- Hao Wu
- Na Zhang
- Xiaofang Sun
- Shengying Qin
Enabling scientific discoveries that improve human health