| Title: | Independent effects of adiposity measures on risk of atrial fibrillation in men and women: a study of 0.5 million individuals |
| Journal: | International Journal of Epidemiology |
| Published: | 25 Sep 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34562082/ |
| DOI: | https://doi.org/10.1093/ije/dyab184 |
| URL: | https://academic.oup.com/ije/article-pdf/51/3/984/44036497/dyab184.pdf |
Publication 5230
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Atrial fibrillation (AF) has a higher prevalence in men than in women and is associated with measures of adiposity and lean mass (LM). However, it remains uncertain whether the risks of AF associated with these measures vary by sex.</p>
METHODS: Among 477 904 UK Biobank participants aged 40-69 without prior AF, 23 134 incident AF cases were identified (14 400 men, 8734 women; median follow-up 11.1 years). Cox proportional hazards models were used to estimate the covariate adjusted hazard ratios (HRs) describing the association of AF with weight, measures of adiposity [fat mass (FM), waist circumference (WC)] and LM, and their independent relevance, by sex.</p>
RESULTS: Weight and WC were independently associated with risk of AF [HR: 1.25 (1.23-1.27) per 10 kg, HR: 1.11 (1.09-1.14) per 10 cm, respectively], with comparable effects in both sexes. The association with weight was principally driven by LM, which, per 5 kg, conferred double the risk of AF compared with FM when mutually adjusted [HR: 1.20 (1.19-1.21), HR: 1.10 (1.09-1.11), respectively]; however, the effect of LM was weaker in men than in women (p-interaction = 4.3 x 10-9). Comparing the relative effects of LM, FM and WC identified different patterns within each sex; LM was the strongest predictor for both, whereas WC was stronger than FM in men but not in women.</p>
CONCLUSIONS: LM and FM (as constituents of weight) and WC are risk factors for AF. However, the independent relevance of general adiposity for AF was more limited in men than in women. The relevance of both WC and LM suggests a potentially important role for visceral adiposity and muscle mass in AF development.</p>
10 Keywords
- Adiposity
- Atrial Fibrillation
- Body Mass Index
- Female
- Humans
- Male
- Obesity
- Prospective Studies
- Risk Factors
- Waist Circumference
12 Authors
- C Fielder Camm
- Ben Lacey
- M Sofia Massa
- Adam Von Ende
- Parag Gajendragadkar
- Alexander Stiby
- Elsa Valdes-Marquez
- Sarah Lewington
- Rohan Wijesurendra
- Sarah Parish
- Barbara Casadei
- Jemma C Hopewell
1 Application
| Application ID | Title |
|---|---|
| 14568 | Elucidating the effects of cardiovascular therapies and drug targets |
Enabling scientific discoveries that improve human health