| Title: | Hematologic Markers and Prostate Cancer Risk: A Prospective Analysis in UK Biobank |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 1 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32457180/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-19-1525 |
| URL: | https://cebp.aacrjournals.org/content/cebp/29/8/1615.full.pdf |
Publication 5114
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Abstract
BACKGROUND: Risk factors for prostate cancer are not well understood. Red blood cell, platelet, and white blood cell indices may be markers of a range of exposures that might be related to prostate cancer risk. Therefore, we examined the associations of hematologic parameters with prostate cancer risk.METHODS: Complete blood count data from 209,686 male UK Biobank participants who were free from cancer at study baseline were analyzed. Participants were followed up via data linkage. After a mean follow-up of 6.8 years, 5,723 men were diagnosed with prostate cancer and 323 men died from prostate cancer. Multivariable-adjusted Cox regression was used to estimate adjusted HRs and 95% confidence intervals (CI) for prostate cancer incidence and mortality by hematologic parameters, and corrected for regression dilution bias.
RESULTS: Higher red blood cell (HR per 1 SD increase = 1.09, 95% CI, 1.05-1.13) and platelet counts (HR = 1.07, 1.04-1.11) were associated with an increased risk of prostate cancer. Higher mean corpuscular volume (HR = 0.90, 0.87-0.93), mean corpuscular hemoglobin (HR = 0.90, 0.87-0.93), mean corpuscular hemoglobin concentration (HR = 0.87, 0.77-0.97), and mean sphered cell volume (HR = 0.91, 0.87-0.94) were associated with a lower prostate cancer risk. Higher white blood cell (HR = 1.14, 1.05-1.24) and neutrophil count (HR = 1.27, 1.09-1.48) were associated with prostate cancer mortality.
CONCLUSIONS: These associations of blood indices of prostate cancer risk and mortality may implicate shared common causes, including testosterone, nutrition, and inflammation/infection among several others in prostate cancer development and/or progression.
IMPACT: These associations provide insights into prostate cancer development and progression.
6 Authors
- Eleanor L Watts
- Aurora Perez-Cornago
- Jaimal Kothari
- Naomi E Allen
- Ruth C Travis
- Timothy J Key
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