| Title: | Fatty Liver Index and Development of Cardiovascular Disease: Findings from the UK Biobank |
| Journal: | Digestive Diseases and Sciences |
| Published: | 29 Mar 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33782808/ |
| DOI: | https://doi.org/10.1007/s10620-021-06954-y |
| Citations: | 31 (22 in last 2 years) as of 8 Aug 2024 |
Publication 4854
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundNonalcoholic fatty liver disease is common and is associated with rising morbidity and mortality in the UK. Cardiovascular disease is the main cause of death in people with nonalcoholic fatty liver disease.AimsTo determine the association between baseline cardiovascular risk factors with fatty liver index, and to investigate the association between fatty liver index and the incidence of cardiovascular disease in the UK.MethodsThis study is a population-based retrospective cohort study using the UK Biobank database.ResultsThe mean fatty liver index in the study cohort was 44.9, and 33.7% met the criteria for nonalcoholic fatty liver disease. Fatty liver index was significantly associated with a wide range of cardiovascular risk factors at baseline. During a mean follow-up of 7.86 years, the combined incidence of cardiovascular disease was 6.92 per 1000-person years at risk. We found significant association between fatty liver index and incident cardiovascular disease in the fully adjusted model. We found significant association between fatty liver index and incident cardiovascular disease in subgroups stratified by BMI as well as subgroups with fatty liver index < 30, < 60, and ≥ 60.ConclusionsFatty liver index not only predicts NAFLD diagnosis, but also indicates baseline and future development of cardiovascular disease on long-term follow-up across weight categories and fatty liver index spectrum. These findings can inform clinicians and other stakeholders on cardiovascular disease management and preventive efforts. Patients with high fatty liver index should be counseled on the increased future risk of developing cardiovascular disease.</p>
15 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cardiovascular Diseases
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Retrospective Studies
- Risk Factors
- United Kingdom
5 Authors
- Biyao Zou
- Yee Hui Yeo
- Ramsey Cheung
- Erik Ingelsson
- Mindie H. Nguyen
Enabling scientific discoveries that improve human health