| Title: | Dose-response associations of cardiorespiratory fitness with all-cause mortality and incidence and mortality of cancer and cardiovascular and respiratory diseases: the UK Biobank cohort study |
| Journal: | British Journal of Sports Medicine |
| Published: | 22 Feb 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30796106/ |
| DOI: | https://doi.org/10.1136/bjsports-2018-099093 |
| URL: | https://eprints.gla.ac.uk/178896/1/178896.pdf |
| Citations: | 79 (26 in last 2 years) as of 8 Aug 2024 |
Publication 4735
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Abstract
OBJECTIVE: To investigate the association of cardiorespiratory fitness with all-cause mortality, and cardiovascular disease (CVD), respiratory disease, chronic obstructive pulmonary disease (COPD) and cancer mortality and incidence.</p>
DESIGN: Prospective population-based study.</p>
SETTING: UK Biobank.</p>
PARTICIPANTS: Of the 5 02 628 (5.5% response rate) participants recruited by UK Biobank, we included 73 259 (14.6%) participants with available data in this analysis. Of these, 1374 participants died and 4210 developed circulatory diseases, 1293 respiratory diseases and 4281 cancer, over a median of 5.0 years (IQR 4.3-5.7) follow-up.</p>
MAIN OUTCOME MEASURES: All-cause mortality and circulatory disease, respiratory disease, COPD and cancer (such as colorectal, lung, breast and prostate) mortality/incidence. Fitness was estimated using a submaximal cycle ergometer test.</p>
RESULTS: The HR for all-cause mortality for each metabolic equivalent of task (MET) higher fitness was 0.96 (95% CI 0.93 to 0.98). Similar results were observed for incident circulatory disease (HR 0.96 [0.95 to 0.97]), respiratory disease (HR 0.96 [0.94 to 0.98]), COPD (HR 0.90 [0.86 to 0.95) and colorectal cancer (HR 0.96 [0.92 to 1.00]). Nonlinear analysis revealed that a high level of fitness (>10METs) was associated with a greater incidence of atrial fibrillation (HR 1.24 [1.07 to 1.44]) and prostate cancer (HR 1.16 [1.02 to 1.32]) compared with average fitness. All results were adjusted for sociodemographic, lifestyle and dietary factors, body composition, and morbidity at baseline and excluded events in the first 2 years of follow-up.</p>
CONCLUSIONS: Higher cardiorespiratory fitness was associated with lower risk of premature mortality and incidence of CVD, respiratory disease and colorectal cancer.</p>
15 Authors
- Lewis Steell
- Frederick K Ho
- Anne Sillars
- Fanny Petermann-Rocha
- Hiu Li
- Donald M Lyall
- Stamatina Iliodromiti
- Paul Welsh
- Jana Anderson
- Daniel F MacKay
- Jill P Pell
- Naveed Sattar
- Jason Mr Gill
- Stuart Robert Gray
- Carlos A Celis-Morales
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