| Title: | Concepts, estimation and interpretation of SNP-based heritability |
| Journal: | Nature Genetics |
| Published: | 1 Sep 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28854176/ |
| DOI: | https://doi.org/10.1038/ng.3941 |
| Citations: | 347 (97 in last 2 years) as of 8 Aug 2024 |
Publication 4593
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Abstract
Jian Yang and colleagues explore the uses and abuses of heritability estimates derived from pedigrees and from GWAS SNPs and make recommendations for best practice in future applications of SNP-based heritability.10 Keywords
- Concept Formation
- Data Interpretation, Statistical
- Genome-Wide Association Study
- Humans
- Models, Genetic
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait, Heritable
- Reproducibility of Results
- Statistics as Topic
5 Authors
- Jian Yang
- Jian Zeng
- Michael E Goddard
- Naomi R Wray
- Peter M Visscher
1 Application
| Application ID | Title |
|---|---|
| 12514 | The limits of predicting complex traits and diseases from genetic data |
Enabling scientific discoveries that improve human health