| Title: | Circulating Phylloquinone Concentrations and Risk of Type 2 Diabetes: a Mendelian Randomization Study |
| Journal: | Diabetes |
| Published: | 23 Oct 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30352877/ |
| DOI: | https://doi.org/10.2337/db18-0543 |
| URL: | https://diabetes.diabetesjournals.org/content/diabetes/68/1/220.full.pdf |
| Citations: | 30 (11 in last 2 years) as of 8 Aug 2024 |
Publication 4503
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Abstract
This study investigated the causal relation between circulating phylloquinone (vitamin K1) concentrations and type 2 diabetes by using a Mendelian randomization (MR) approach. We used data from three studies: the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, Diabetes Genetics Replication and Meta-analysis (DIAGRAM), and the UK Biobank, resulting in 69,647 subjects with type 2 diabetes. We calculated a weighted genetic risk score including four genetic variants previously found to be associated with circulating phylloquinone concentrations. Inverse-variance weighted analysis was used to obtain a risk ratio (RR) for the causal relation between circulating phylloquinone concentrations and risk of type 2 diabetes. Presence of pleiotropy and the robustness of the results were assessed using MR-Egger and weighted-median analyses. Genetically predicted concentrations of circulating phylloquinone were associated with lower risk of type 2 diabetes with an RR of 0.93 (95% CI 0.89; 0.97) per every natural logarithm (Ln)-nmol/L-unit increase in circulating phylloquinone. The MR-Egger and weighted median analyses showed RRs of 0.94 (0.86; 1.02) and 0.93 (0.88; 0.98), respectively, indicating no pleiotropy. In conclusion, our study supports that higher circulating phylloquinone may be causally related with lower risk of type 2 diabetes, highlighting the importance of sufficient phylloquinone in the human diet.</p>
10 Keywords
- Cohort Studies
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Genotype
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Prospective Studies
- Risk Factors
- Vitamin K 1
10 Authors
- Sabine R Zwakenberg
- Sharon Remmelzwaal
- Joline W J Beulens
- Sarah L Booth
- Stephen Burgess
- Hassan S Dashti
- Fumiaki Imamura
- Edith J M Feskens
- Yvonne T van der Schouw
- Ivonne Sluijs
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