| Title: | BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization |
| Journal: | Obesity |
| Published: | 25 Oct 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30358150/ |
| DOI: | https://doi.org/10.1002/oby.22313 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.22313 |
Publication 4374
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Abstract
OBJECTIVE: The aim of this study was to obtain estimates of the causal relationship between BMI and mortality.</p>
METHODS: Mendelian randomization (MR) with BMI-associated genotypic variation was used to test the causal effect of BMI on all-cause and cause-specific mortality in UK Biobank participants of White British ancestry.</p>
RESULTS: MR analyses supported a causal association between higher BMI and greater risk of all-cause mortality (hazard ratio [HR] per 1 kg/m2 : 1.03; 95% CI: 0.99-1.07) and mortality from cardiovascular diseases (HR: 1.10; 95% CI: 1.01-1.19), specifically coronary heart disease (HR: 1.12; 95% CI: 1.00-1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95% CI: 1.03-1.48), stomach cancer (HR: 1.18; 95% CI: 0.87-1.62), and esophageal cancer (HR: 1.22; 95% CI: 0.98-1.53), and a decreased risk of lung cancer mortality (HR: 0.96; 95% CI: 0.85-1.08). Sex stratification supported the causal role of higher BMI increasing bladder cancer mortality risk (males) but decreasing respiratory disease mortality risk (males). The J-shaped observational association between BMI and mortality was visible with MR analyses, but the BMI at which mortality was minimized was lower and the association was flatter over a larger BMI range.</p>
CONCLUSIONS: Results support a causal role of higher BMI in increasing the risk of all-cause mortality and mortality from several specific causes.</p>
9 Keywords
- Biological Specimen Banks
- Body Mass Index
- Female
- Humans
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Mortality
- United Kingdom
5 Authors
- Kaitlin H. Wade
- David Carslake
- Naveed Sattar
- George Davey Smith
- Nicholas J. Timpson
1 Application
| Application ID | Title |
|---|---|
| 16391 | Investigating causal effects of accelerometer measures and body composition on chronic disease |
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