| Title: | Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the MTNR1B Gene |
| Journal: | Diabetes Care |
| Published: | 2 Jul 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32616615/ |
| DOI: | https://doi.org/10.2337/dc20-0507 |
| URL: | https://diabetesjournals.org/care/article-pdf/43/9/2289/630915/dc200507.pdf |
Publication 3692
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Abstract
OBJECTIVE: The common MTNR1B single nucleotide polymorphism rs10830963 associates with risk of type 2 diabetes (T2D). Here, we examine the association between this gene variant and the risk of myocardial infarction (MCI) among patients with T2D. MCI is a main cause of death and disability among such individuals.</p>
RESEARCH DESIGN AND METHODS: Data from the UK Biobank cohort were used in order to examine the association between rs10830963 and incidence of MCI (fatal and nonfatal) among 13,655 participants with probable T2D during a follow-up period of 6.8 years.</p>
RESULTS: Assuming an additive genetic model, a positive association was found between the rs10830963 variant in the MTNR1B gene and the risk for incident MCI during the 6.8-year follow-up (adjusted hazard ratio per G allele 1.19 [95% CI 1.02, 1.40], P = 0.03).</p>
CONCLUSIONS: The rs10830963 polymorphism may be a useful genetic marker for MCI in patients with T2D.</p>
20 Keywords
- Adult
- Aged
- Alleles
- Cohort Studies
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Female
- Follow-Up Studies
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
- Polymorphism, Single Nucleotide
- Receptor, Melatonin, MT2
- Risk Factors
- United Kingdom
2 Authors
- Xiao Tan
- Christian Benedict
1 Application
| Application ID | Title |
|---|---|
| 43015 | Melatonin, lifestyle, and health: a gene-environmental investigation in the UK Biobank |
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