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Abstract
Pancreatic cancer is one of the most fatal cancer types characterized by an increased incidence in western industrialized countries. Metabolic syndrome (MetS) has become a major public health problem. However, evidence on the effects of MetS and its components on the risk of pancreatic cancer is limited, and the potential mechanisms underlying the association remain unclear. Based on the prospective UK Biobank cohort, this study identified the dominant MetS components related to pancreatic cancer, examined the potential non-linear associations between MetS components and pancreatic cancer and evaluated the joint effect of MetS and C-reactive protein, a sensitive biochemical indicator to assess varying inflammatory status, with pancreatic cancer risk. Results showed that MetS is associated with increased risk of pancreatic cancer in general population. Waist circumference and fasting blood glucose were two predominant MetS components that might be independently associated with pancreatic cancer risk in a linear manner. Our results suggested a potential joint effect of MetS and CRP in pancreas tumorigenesis, and provide novel insights underlying the pathological changes for pancreatic cancer development.