| Title: | The effect of smoking intensity on all-cause and cause-specific mortality - a Mendelian randomization analysis |
| Journal: | International Journal of Epidemiology |
| Published: | 10 May 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31074779/ |
| DOI: | https://doi.org/10.1093/ije/dyz081 |
| URL: | https://academic.oup.com/ije/article-pdf/48/5/1438/30802448/dyz081.pdf |
| Citations: | 14 (1 in last 2 years) as of 8 Aug 2024 |
Publication 2824
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Abstract
BACKGROUND: Smoking is an important cause of mortality and recent studies have suggested that even low-intensity smoking might be associated with increased mortality. Still, smoking is associated with lower socio-economic status as well as other potential risk factors, and disease onset might motivate smoking cessation, thus residual confounding and reverse causality might bias results. We aimed to assess the evidence of a causal relationship between smoking intensity and cause-specific as well as all-cause-mortality using Mendelian randomization analyses.</p>
METHODS: We included 56 019 participants from the Norwegian HUNT2 Study and 337 103 participants from UK Biobank, linked to national registry data on causes of death. We estimated associations of self-reported smoking as well as the genetic variant rs1051730 as an instrument for smoking intensity with all-cause and cause-specific mortality. We subsequently meta-analysed the results from the two cohorts.</p>
RESULTS: Each effect allele of the rs1051730 was associated with a 9% increased hazard of all-cause mortality [95% confidence interval (CI) 6-11] among ever smokers. Effect alleles were also associated with death by neoplasms [hazard ratio (HR) 1.11, 95% CI 1.06-1.15], circulatory diseases (HR 1.06, 95% CI 1.01-1.11) and respiratory diseases (HR 1.15, 95% CI 1.05-1.26) among ever smokers. The association was stronger among ever than never smokers for all-cause mortality (p < 0.001), neoplasms (p = 0.001) and respiratory diseases (p = 0.038).</p>
CONCLUSIONS: Our results indicate a causal effect of smoking intensity on all-cause mortality and death by neoplasms and respiratory diseases. There was weaker evidence of a causal effect of smoking intensity on death by circulatory diseases.</p>
9 Authors
- Gunnhild Åberge Vie
- Robyn E Wootton
- Johan Håkon Bjørngaard
- Bjørn Olav Åsvold
- Amy E Taylor
- Maiken Elvestad Gabrielsen
- George Davey Smith
- Pål Richard Romundstad
- Marcus R Munafò
1 Application
| Application ID | Title |
|---|---|
| 9142 | Using Mendelian Randomisation to investigate the causal effects of caffeine and smoking on health outcomes. |
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