| Title: | Evidence for Genetic Correlations and Bidirectional, Causal Effects Between Smoking and Sleep Behaviors |
| Journal: | Nicotine Tob Res |
| Published: | 21 May 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30365022/ |
| DOI: | https://doi.org/10.1093/ntr/nty230 |
Publication 2822
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Abstract
Cigarette smokers are at increased risk of poor sleep behaviors. However, it is largely unknown whether these associations are due to shared (genetic) risk factors and/or causal effects (which may be bidirectional). We used publicly available data and data from UK Biobank to investigate whether the relationship between smoking and sleep was likely to be due to shared genetic causes or a causal effect of one of these behaviours on the other. We found negative genetic correlations between smoking initiation and sleep and smoking cessation and chronotype (being a morning person) and positive genetic correlations between smoking initiation and insomnia and cigarettes per day and insomnia. We found evidence that smoking more cigarettes causally decreases the odds of being a morning person and weak evidence that insomnia causally increases smoking heaviness and decreases likelihood of smoking cessation.9 Keywords
- Genetic Markers
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Prevalence
- Sleep Initiation and Maintenance Disorders
- Smoking
- United Kingdom
1 Author
- Gibson M et al.
1 Application
| Application ID | Title |
|---|---|
| 9142 | Using Mendelian Randomisation to investigate the causal effects of caffeine and smoking on health outcomes. |
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