| Title: | Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank |
| Journal: | Journal of the American Heart Association |
| Published: | 28 Feb 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29490971/ |
| DOI: | https://doi.org/10.1161/jaha.117.008507 |
| URL: | https://www.ahajournals.org/doi/pdf/10.1161/JAHA.117.008507 |
Publication 2789
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Abstract
BACKGROUND: There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex-specific relationships and their differences between measures of general and central adiposity and the risk of incident myocardial infarction (MI).</p>
METHODS AND RESULTS: Between 2006 and 2010, the UK Biobank recruited over 500 000 participants aged 40 to 69 years across the United Kingdom. During 7 years of follow-up, 5710 cases of MI (28% women) were recorded among 265 988 women and 213 622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios for MI associated with body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio. There was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI in both sexes. A 1-SD higher in body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio, respectively, were associated with hazard ratios (confidence intervals) for MI of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), and 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women-to-men ratios of hazard ratios were 0.96 (0.91; 1.02), 1.07 (1.00; 1.14), 1.15 (1.06; 1.24), and 1.03 (0.97; 1.09).</p>
CONCLUSIONS: Although general and central adiposity measures each have profound deleterious effects on the risk of MI in both sexes, a higher waist circumference and waist-to-hip ratio conferred a greater excess risk of MI in women than in men. Waist-to-hip ratio was more strongly associated with the risk of MI than body mass index in both sexes, especially in women.</p>
21 Keywords
- Adiposity
- Adult
- Aged
- Body Mass Index
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
- Obesity, Abdominal
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Sex Distribution
- Sex Factors
- Time Factors
- United Kingdom
- Waist Circumference
- Waist-Hip Ratio
3 Authors
- Sanne A. E. Peters
- Sophie H. Bots
- Mark Woodward
1 Application
| Application ID | Title |
|---|---|
| 2495 | Sex differences in the association between major and modifiable risk factors with cardiovascular disease |
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