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Abstract
In this study, UK Biobank data from almost 130,000 people were studied to examine the relationship between the genetic risk factors for trauma exposure and depression, looking at those people who do and do not report exposure to traumatic events. The genetic risk for developing depression when people had reported being exposed to trauma was found to be double that for people who didn t report trauma exposure. Simulations showed that this was not confounded by the strong, positive genetic correlation between depression and reported trauma exposure. Furthermore, the findings also provided evidence that reported trauma exposure is partially heritable.
Note: GWAS analyses from this study contributed towards a further publication (Dalvie et al, 2020) which is also attached.