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Abstract
We performed a population-based genetic association study of all-cause heart failure that yielded multiple genetic signals for known heart failure risk factors, such as coronary artery disease and atrial fibrillation. Refining the heart failure phenotype to a non-ischemic cardiomyopathy subset enhanced the detection of genetic loci associated with dilated cardiomyopathy, which appear to operate independent of traditional heart failure risk factors. Genetic variants associated with nonischemic cardiomyopathy were also associated with subclinical traits of left ventricular dysfunction.