| Title: | Night-Shift Intensity, Duration, Cardiovascular Susceptibility and Incident Cardiovascular Disease: UK Biobank Study |
| Journal: | The American Journal of Medicine |
| Published: | 22 Jun 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42331049/ |
| DOI: | https://doi.org/10.1016/j.amjmed.2026.06.016 |
Publication 20584
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Abstract
OBJECTIVE: Night-shift work has been associated with adverse cardiovascular outcomes. It remains unclear whether the cardiovascular association of night-shift exposure differs according to underlying baseline cardiovascular susceptibility and whether short-term intensity and longer-term duration show similar patterns.</p>
METHODS: We analyzed 85,322 UK Biobank participants with occupational night-shift information. Baseline cardiovascular disease risk profile was classified as low, intermediate, or high using a composite score based on cardiovascular disease polygenic risk score tertiles, current smoking, obesity, low moderate-to-vigorous physical activity, and insomnia. Night-shift exposure was evaluated in two ways: monthly intensity and yearly duration, each categorized as none, low, or high. Incident cardiovascular disease was identified from inpatient records. Cox proportional hazards models were evaluated for the associations.</p>
RESULTS: Of 85,322 participants, 24,696 were classified as low cardiovascular disease risk, 49,332 as intermediate risk, and 11,294 as high risk. Across all strata, workers without night-shift exposure generally had the lowest incidence of cardiovascular disease . In the low-risk group, high monthly intensity and high yearly duration were each associated with similar increased risk and having more pronounced in high-risk group. For monthly intensity, the aHR were 1.35 (95% CI 1.19-1.52) and 1.22 (95% CI 1.08-1.37) for low- and high-intensity groups, respectively, whereas for yearly duration the corresponding aHR were 1.21 (95% CI 1.06-1.37) and 1.34 (95% CI 1.19-1.51).</p>
CONCLUSIONS: Among workers with occupational night-shift information, the association between night-shift exposure and incident cardiovascular disease was strongest in those with greater baseline cardiovascular susceptibility. Compared with monthly intensity, yearly duration showed a more consistent exposure-response pattern.</p>
1 Author
- Yohwan Lim
1 Application
| Application ID | Title |
|---|---|
| 106954 | Development of depression and chronic disease management service in primary care by investigating associated risk factors |
Enabling scientific discoveries that improve human health