| Title: | Aligning patient and planetary health: planetary health diet adherence and inflammatory bowel disease prognosis across Western and Eastern cohorts |
| Journal: | npj Science of Food |
| Published: | 29 Jun 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42373652/ |
| DOI: | https://doi.org/10.1038/s41538-026-00959-5 |
Publication 20516
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Abstract
This study aims to evaluate whether planetary health diet (PHD) could be a potential tool to achieve sustainability in IBD management. We included 1455 IBD participants from the UK Biobank (UKB) and 205 from the ONE-IBD cohort. Dietary intake was captured through validated questionnaires and seven PHD adherence algorithms were evaluated. Environmental impact was estimated using dietary carbon footprints. Outcomes included IBD-related surgery, colorectal cancer, and all-cause mortality in the UKB, while readmission and recurrence in ONE-IBD. Cox models estimated hazard ratios (HRs) with 95% confidence intervals (CIs). During a median 10.5-year follow-up, 191 surgeries, 78 CRC, and 232 deaths occurred. Adherence to PHD were inversely associated with surgery risk (HRper SD 0.67-0.80). All algorithms were linked to lower dietary carbon footprints (r −0.061 to −0.468). A modified-Knuppel algorithm provided similar protection (HRper SD = 0.73, 95% CI 0.60-0.89) and environmental correlation (r = −0.244). In ONE-IBD, the modified algorithm was associated with lower readmission risk (HRper SD = 0.80, 95% CI 0.65-1.00). Proteomics data suggest potential benefits through improved intestinal barrier integrity and reduced fibrosis. To conclude, higher PHD adherence is associated with better IBD outcomes and lower environmental burden, supporting that the PHD may represent a promising and sustainable dietary pattern in IBD management.</p>
14 Authors
- Lintao Dan
- Haiting Shu
- Yuhao Sun
- Judith Wellens
- Yang Chen
- Minzi Deng
- Jialu Yao
- Xixian Ruan
- Henit Yanai
- Xue Li
- Britta Siegmund
- Xiaoyan Wang
- Fernando Magro
- Jie Chen
1 Application
| Application ID | Title |
|---|---|
| 232231 | Deciphering the impact of environmental determinants on digestive system disease and other chronic diseases based on the multi-omic data |
Enabling scientific discoveries that improve human health