| Title: | Sarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank. |
| Journal: | Diabetes Care |
| Published: | 13 Jul 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42439362/ |
| DOI: | https://doi.org/10.2337/dc26-0797 |
Publication 20366
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Abstract
OBJECTIVE: To examine whether sarcopenic obesity (SO) is associated with incident type 2 diabetes (T2D) beyond obesity or sarcopenia alone and whether associations differ by sex, age, and transitions in body composition phenotypes over time.</p>
RESEARCH DESIGN AND METHODS: We studied 479,607 diabetes-free UK Biobank participants. SO was defined using handgrip strength, skeletal muscle mass-to-weight ratio, and fat mass percentage. Cox models estimated hazard ratios (HRs). A landmark analysis (n = 53,107) examined phenotype transitions.</p>
RESULTS: Over a median follow-up of 14.2 years, T2D developed in 32,948 participants. SO conferred the highest risk (HR 3.54 [95% CI 3.34-3.74]), exceeding obesity alone and sarcopenia alone. Transitioning to SO (HR 2.90 [95% CI 2.07-4.07]) and persistent SO (HR 3.07 [95% CI 1.63-5.79]) both elevated risks.</p>
CONCLUSIONS: SO was associated with higher T2D risk than obesity or sarcopenia alone, supporting integrated assessment of muscle health and adiposity in T2D risk stratification.</p>
3 Authors
- Zhongyang Guan
- Blossom C M Stephan
- Mario Siervo
1 Application
| Application ID | Title |
|---|---|
| 363248 | Exploring the association between sarcopenic obesity and cardiometabolic and neurological health in the UK Biobank cohort |
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