| Title: | Adherence to the EAT-Lancet Diet, Genetic Predisposition, and Risk of Kidney Stone Disease: A Population-Based Prospective Cohort Study |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 13 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41833906/ |
| DOI: | https://doi.org/10.1016/j.ajcnut.2026.101278 |
Publication 17385
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Abstract
BACKGROUND: The EAT-Lancet diet was developed to promote both human health and environmental sustainability. However, the association between the EAT-Lancet diet and kidney stone disease (KSD) risk remains unclear.</p>
OBJECTIVE: We aimed to investigate the association between adherence to the EAT-Lancet diet and KSD risk, evaluate the mediating role of body mass index (BMI), and explore whether genetic predisposition modifies these associations.</p>
METHODS: This prospective cohort study included 197,759 adults who completed at least one 24-hour dietary recall and were free of KSD from the UK Biobank. The EAT-Lancet Diet Index (ELD-I) was calculated using these recall data to assess the adherence to the EAT-Lancet diet. A polygenic risk score (PRS) was constructed using 20 single-nucleotide polymorphisms (SNPs) to evaluate genetic predisposition. Cox proportional hazards regression models were used to assess the associations between ELD-I, genetic predisposition, and KSD risk. The mediating role of body mass index (BMI) was also investigated.</p>
RESULTS: After 2,286,927 person-years of follow-up, 1,708 incident KSD cases were identified. In the multivariable-adjusted model, compared to participants with the lowest ELD-I, the hazard ratio (HR) and 95% confidence interval (CI) for participants with the highest ELD-I was 0.81 (0.69, 0.95). Mediation analysis indicated that BMI mediated 14.94% of the association between ELD-I and KSD risk. Moreover, no significant interaction between the genetic predisposition of KSD and ELD-I was observed. Joint analyses showed that compared to participants with the lowest ELD-I and higher genetic predisposition, the HR (95% CI) of those with the highest ELD-I and lower genetic predisposition was 0.61 (0.49, 0.76).</p>
CONCLUSION: Higher adherence to the EAT-Lancet diet was inversely associated with KSD among people with different genetic predispositions, and the association was partly mediated by BMI.</p>
7 Authors
- Kun Xu
- Fengyue Wu
- Lei Na
- Junlong Liu
- Peng Wang
- Yashu Liu
- Song Bai
1 Application
| Application ID | Title |
|---|---|
| 524293 | The Role of Nutrition and Healthy Lifestyles in Metabolic, Cardiovascular, and Aging-Related Diseases: Impacts on Healthy Aging |
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