| Title: | Association of childhood adversity with all-cause mortality risk and cardio-cerebrovascular disease mortality risk: A cohort study in the UK Biobank |
| Journal: | Journal of Affective Disorders |
| Published: | 29 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41325806/ |
| DOI: | https://doi.org/10.1016/j.jad.2025.120784 |
Publication 16819
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Abstract
BACKGROUND: The association between childhood adversity and all-cause mortality risk as well as cardio-cerebrovascular disease mortality risk, and whether this differs by sex, remain unknown.</p>
METHODS: A population-based cohort analysis was conducted using baseline data from the UK Biobank (2006-2010) and online psychological health survey (2016). Childhood adversities included physical neglect, emotional neglect, sexual abuse, physical abuse, and emotional abuse. Cox proportional hazards models were used to investigate the association of childhood adversity with all-cause mortality risk and cardio-cerebrovascular disease mortality risk, with stratified analyses by sex.</p>
RESULTS: The study included 153,294 participants with a median age of 57 years, comprising 86,335 females (56.3 %). In fully adjusted models, participants experiencing physical neglect (HR = 1.17; 95 % CI: 1.09-1.25), physical abuse (HR = 1.08; 95 % CI: 1.00-1.16) and emotional abuse (HR = 1.17; 95 % CI: 1.08-1.27) both showed higher risk of all-cause mortality. Notably, participants experiencing one childhood adversity showed significantly lower risk of heart disease mortality (HR = 0.80; 95 % CI: 0.67-0.97) and ischemic disease mortality (HR = 0.74; 95 % CI: 0.59-0.93) compared to those who did not experience childhood adversity. Participants experiencing physical neglect also had a higher risk of cerebrovascular disease mortality (HR = 1.60; 95 % CI: 1.19-2.14). Sex-stratified analyses revealed that male or female participants experiencing physical neglect and emotional abuse both had a higher risk of all-cause mortality. Sensitivity analyses showed similar findings to the primary analysis.</p>
CONCLUSION: Individuals experiencing physical neglect were significantly associated with increased risk of all-cause mortality and cerebrovascular disease mortality, underscoring the importance of early prevention screening and psychological intervention strategies.</p>
13 Authors
- Jiayue Xia
- Yuanyuan Wang
- Zhenzhen Zhang
- Jiongnan Wang
- Shiyu Yin
- Zhiyuan Feng
- Junhui Yu
- Xingyi Jin
- Yilu Chen
- Wei Yan
- Tianyu Wu
- Da Pan
- Guiju Sun
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