| Title: | Air pollution exposure modes, smoking and genetic risk with chronic respiratory diseases: a prospective study |
| Journal: | npj Primary Care Respiratory Medicine |
| Published: | 5 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41350531/ |
| DOI: | https://doi.org/10.1038/s41533-025-00469-z |
| URL: | https://www.nature.com/articles/s41533-025-00469-z_reference.pdf |
Publication 16741
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Previous studies often focused on single pollutant source, failing to replicate real-world exposure scenarios for chronic respiratory disease (CRD) risk. We aimed to explore the mixed exposure patterns of CRD risk factors and investigate interactions with smoking and genetic risk. We identified air pollution exposure modes using latent class analysis (LCA) in the UK Biobank. Cox model assessed associations between exposure modes and lung cancer (LC), idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma. Interactions among exposure modes, smoking and genetic risk were analyzed. LCA divided participants into five groups, and hazard ratios (HRs) for "High air pollution" group were 1.28 for LC (95% CI: 1.08-1.52), 1.23 for IPF (95% CI: 1.03-1.48), 1.28 for COPD (95% CI: 1.17-1.39) and 1.09 for asthma (95% CI: 1.01-1.18). Significant additive interactions between high air pollution and smoking were observed for LC and COPD. Individuals with high genetic risk exposed to both smoking and high air pollution showed the relative excess risk due to interaction (RERI) of 2.74 for LC, 3.93 for IPF, and 1.68 for COPD. Smoking and air pollution together accounted for over 40% of LC, IPF and COPD cases. Our findings highlight the complex interplay between environmental air pollution, smoking, and genetic risk in CRD development in real-world exposure scenarios.</p>
7 Authors
- Ting Wang
- Linfang Lyu
- Ru Yuan
- Lei Lei
- Fanqing Meng
- Meng Zhu
- Weiwei Duan
1 Application
| Application ID | Title |
|---|---|
| 617693 | Associations of genetic factors, healthy lifestyle behavior, and environmental pollution with common chronic diseases |
Enabling scientific discoveries that improve human health