| Title: | Association between atherogenic index of plasma and incident aortic disease: a population-based prospective analysis |
| Journal: | Open Heart |
| Published: | 1 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41073128/ |
| DOI: | https://doi.org/10.1136/openhrt-2025-003511 |
| URL: | https://openheart.bmj.com/content/12/2/e003511.full.pdf |
Publication 16653
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Abstract
OBJECTIVE: To clarify whether atherogenic index of plasma (AIP), a comprehensive indicator reflecting both the protective and atherogenic effects of lipoproteins on cardiometabolic health, is associated with increased risk of aortic disease.</p>
DESIGN: Large-scale, population-based, observational, prospective cohort study.</p>
DATA SOURCES: Health dataset from UK Biobank.</p>
PARTICIPANTS: A total of 17 530 participants, aged 40-70 years, were enrolled and completed the initial assessment visit before 2010. Participants with a history of aortic dissection (AD) or aortic aneurysm (AA), baseline connective tissue disease, missing triglyceride and high-density lipoprotein cholesterol values, fasting time less than 8 hours or those lost to follow-up were excluded.</p>
MAIN OUTCOME MEASURES: Aortic disease, a composite outcome comprising AD and AA.</p>
RESULTS: During a median follow-up period of 15.1 years, 164 aortic disease cases, including 14 AD and 155 AA cases, were documented. A linear trend between AIP and the risk of incident aortic disease was confirmed (p for non-linear=0.134). The multivariable-adjusted incident risk of aortic disease gradually increased with elevated AIP tertiles (adjusted HR (aHR) 1.0 (reference) in tertile 1, aHR 1.48 (95% CI 0.91 to 2.41) in tertile 2, aHR 2.04 (95% CI 1.26 to 3.29) in tertile 3), following an adjustment for age, sex, smoking status, drinking status, body mass index, hypertension, low-density lipoprotein cholesterol and glycated haemoglobin. Specifically, participants in the highest AIP tertile had the highest incident risk of AA, with an aHR of 2.47 (95% CI 1.47 to 4.16).</p>
CONCLUSIONS: AIP is significantly associated with a higher risk of incident aortic disease, indicating that AIP is an effective risk assessment method for aortic disease, especially for AA.</p>
17 Keywords
- Adult
- Aged
- Aortic Aneurysm
- Aortic Diseases
- Atherosclerosis
- Biomarkers
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Population Surveillance
- Prospective Studies
- Risk Assessment
- Risk Factors
- United Kingdom
8 Authors
- Cuihong Tian
- Xiao Wang
- Liang Tao
- Wanyi Wei
- Xuan Zhang
- Haoxian Tang
- Yequn Chen
- Xuerui Tan
1 Application
| Application ID | Title |
|---|---|
| 205837 | Integrated omics to implore risk, diagnostic, and prognostic factors of cardiovascular disease |
Enabling scientific discoveries that improve human health