| Title: | Association Between Trunk Fat Mass Index and Diabetes in a Multinational Population |
| Journal: | Mayo Clinic Proceedings Innovations Quality & Outcomes |
| Published: | 19 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41036431/ |
| DOI: | https://doi.org/10.1016/j.mayocpiqo.2025.100658 |
| URL: | https://www.mcpiqojournal.org/article/S2542-4548(25)00069-4/pdf |
Publication 16595
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Abstract
Objective: To examine the cross-sectional association between trunk fat mass index (TFMI) and diabetes across individuals within the same body mass index (BMI [calculated as the weight in kilograms divided by the height in meters squared]) categories in a multinational population.</p>
Participants and Methods: We harmonized and pooled data on 57,764 individuals aged 40 years and older from the United Kingdom, the United States, and South Korea. Trunk fat mass imaging was performed using a dual-energy X-ray absorptiometry device during 2015-2023 in the United Kingdom, 2011-2018 in the United States, and 2008-2011 in South Korea. The prevalence of diabetes was derived from the self-reported medical history. Additionally, plasma biochemistry analyses were conducted to update the number of participants with diabetes.</p>
Results: Among participants classified as having a normal weight based on BMI, the relative risks (RRs) of diabetes increased from TFMI quintiles 1 to 5 with the linear trend (P<.001). The risk of diabetes among individuals in TFMI quintile 5 was around 3 times greater than those in quintile 1 (men-RR, 3.06; 95% confidence interval [CI], 2.17-4.34; women-3.35; 95% CI, 2.08-5.39). This significant linear trend (P<.001) in RRs was also present in overweight and obese individuals (overweight men-RR, 1.92; 95% CI, 1.50-2.47; overweight women-RR, 2.25; 95% CI, 1.73-2.91; obese men-RR, 2.47; 95% CI, 1.83-3.35; obese women-2.79; 95% CI, 2.04-3.83).</p>
Conclusion: Within a specific BMI category, individuals with a high trunk fat mass are more likely to experience diabetes compared with those with lower levels of central fat.</p>
12 Authors
- Chibueze Ogbonnaya
- Madison Kindred
- Carl J. Lavie
- Hannah Oh
- Min-Jeong Shin
- Xuemei Sui
- Jason Jaggers
- Ryan Porter
- Dahyun Park
- Jin E. Kim
- Jessica Gong
- Vivek K. Prasad
1 Application
| Application ID | Title |
|---|---|
| 70816 | Body Composition (BC) Studies Collaboration (BCSC) Project |
Enabling scientific discoveries that improve human health