| Title: | Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility |
| Journal: | Journal of Alzheimer's Disease Reports |
| Published: | 1 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40919418/ |
| DOI: | https://doi.org/10.1177/25424823251370717 |
Publication 16445
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Abstract
Background: Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported.</p>
Objective: This study explored the effects of miscarriage and stillbirth on future dementia risk in women.</p>
Methods: The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined.</p>
Results: For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia.</p>
Conclusions: Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score.</p>
8 Authors
- Qiaoqiao Xu
- Chengzhe Tao
- Sijia Dai
- Zhixi Lu
- Michael Aschner
- Guangfeng Long
- Shaojun Li
- Cheng Xu
1 Application
| Application ID | Title |
|---|---|
| 140851 | The impact of social factors, lifestyle, psychological status, environmental factors, and genetic factors on the occurrence, progression, and mortality risk of chronic noncommunicable diseases |
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