| Title: | The association of n-3 fatty acid intake with muscle mass and strength in older adults: A cross-sectional analysis of the UK biobank data |
| Journal: | The journal of nutrition, health & aging |
| Published: | 27 Jun 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40580825/ |
| DOI: | https://doi.org/10.1016/j.jnha.2025.100622 |
Publication 16398
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Abstract
OBJECTIVES: The main aim was to investigate the association of n-3 fatty acid intake and the n-6/n-3 fatty acid intake ratio with muscle mass and strength in older adults.</p>
METHODS: This study included 61,381 individuals (28,187 men and 33,194 women) aged ≥60 years. Grip strength and muscle mass index were assessed and n-3 and n-6 fatty acid intake were determined. Regression models adjusted for age, deprivation index, ethnicity, month of assessment, total energy intake, multimorbidity, lifestyle factors and physical activity. A sensitivity analysis was conducted in participants aged ≥65 years and in people with sarcopenia.</p>
RESULTS: Data are presented as trend for quintiles from fully adjusted models. Higher n-3 fatty acid intake was associated with a higher grip strength in both men (0.114 kg; 95% CI: 0.02 to 0.21) and women (0.115 kg; 95% CI: 0.05 to 0.18). Similar results were reported for grip strength index, with no associations observed for muscle mass index. No associations were seen in people ≥65 years. In people with sarcopenia no associations of n-3 fatty acid intake with grip strength or grip strength index were seen, but a positive association with muscle mass index was noted in men (0.197 kg/m²; 95% CI: 0.05 to 0.33). The n-6/n-3 fatty acid intake ratio was associated with grip strength in women (0.081 kg; 95% CI: -0.16 to 0.000) and with muscle mass index in men (-0.016 kg/m²; 95% CI: -0.02 to 0.00), no other associations were observed. No associations were seen in people with sarcopenia or people ≥65 years.</p>
CONCLUSION: Higher n-3 fatty acid intake, with no consistent association with the n-6/n-3 fatty acid intake, was modestly associated with grip strength, with effects varying by sex and age, suggesting limited benefit for sarcopenia prevention at typical intake levels in older adults.</p>
6 Authors
- Maha Timraz
- Marion Guerrero Wyss
- Terry J Quinn
- Emilie Combet
- Carlos Celis-Morales
- Stuart R Gray
1 Application
| Application ID | Title |
|---|---|
| 71392 | Investigating complex relationships between genetics, exposures, biomarkers, endophenotypes and cardiometabolic, inflammatory, immune and brain-related health outcomes |
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