| Title: | Body roundness index and mental health in middle-aged and elderly adults: a prospective cohort study |
| Journal: | Scientific Reports |
| Published: | 2 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40593122/ |
| DOI: | https://doi.org/10.1038/s41598-025-06994-8 |
| URL: | https://www.nature.com/articles/s41598-025-06994-8.pdf |
Publication 16382
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The global rise in mental disorders presents a significant public health challenge, highlighting the need for a deeper understanding of their underlying risk factors. Existing studies on obesity and brain health primarily rely on metrics such as body mass index and waist-to-hip ratio, which inadequately capture central obesity, a fat distribution strongly associated with increased health risks. This underscores the need for more precise metrics, with the body roundness index (BRI) emerging as a promising option. 321,596 UK Biobank participants were analyzed in this study. Cox regression models assessed associations between BRI and incident mental disorders, while logistic and multiple linear regression models explored relationships with psychiatric symptoms and white matter integrity, respectively. Results indicated that higher BRI was significantly associated with increased risks of incident overall mental disorders (HR [95% CI] = 1.12 [1.09, 1.15]), as well as specific high-prevalence disorders including substance use disorder (1.05 [1.01, 1.11]), depressive disorder (1.34 [1.24, 1.45]), and anxiety disorder (1.09 [1.03, 1.15]). An overall positive association was also observed between elevated BRI and adverse psychiatric symptoms and reduced white matter integrity. These findings highlighted BRI as a potential indicator of mental health. BRI's association with clinical and subclinical psychiatric outcomes emphasized its relevance in understanding the interplay between central adiposity and brain health.</p>
11 Keywords
- Aged
- Body Mass Index
- Female
- Humans
- Male
- Mental Disorders
- Mental Health
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
10 Authors
- Jiawei Gu
- Yujia Bao
- Yongxuan Li
- Xuhua Chen
- Shenghao Yuan
- Yuzheng Zhang
- Haozhi Pan
- Xiaobei Deng
- Lefei Han
- Jinjun Ran
1 Application
| Application ID | Title |
|---|---|
| 99001 | Gene-environment interaction analysis on age-related diseases |
Enabling scientific discoveries that improve human health