| Title: | Long-term exposure to ambient air pollution and incident nephritis: A prospective cohort study in the UK Biobank |
| Journal: | Atmospheric Pollution Research |
| Published: | 1 Jul 2025 |
| DOI: | https://doi.org/10.1016/j.apr.2025.102524 |
Publication 16359
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Abstract
Substantial studies have highlighted the implications of air pollution in relation to several kidney diseases. However, studies on the relationships of long-term exposure to NO2, NOx, PM2.5, PM2.5-10, PM10 with the incidence of nephritis are relatively scarce. In our prospective cohort study, 446,626 participants from the UK Biobank who had no kidney diseases at baseline were enrolled. Annual concentrations of particulate matter (PM) with diameters ≤2.5 μm (PM2.5), between 2.5 and 10 μm (PM2.5-10), and ≤10 μm (PM10), as well as nitrogen dioxide (NO2) and nitrogen oxides (NOx) were gauged by land-use regression models. We employed Cox proportional hazards models to examine the associations of air pollutants with the incidence of nephritis, adjusted for potential covariates. We applied restricted cubic spline (RCS) analysis to find the exposure-response relationship. 3,455 cases were observed through a median follow-up duration of 13.58 years. Our results showed the enhanced risk of nephritis was linked to per interquartile range (IQR) increase in NO2 (hazard ratio (HR): 1.09, 95 % confidence intervals (95 %CI): 1.04-1.14) and in NOx (1.05, 1.01-1.08). We found nonlinear relationships between the levels of NOx, PM2.5, and PM2.5-10 and incident nephritis. They all displayed a tendency of initial rapid increase followed by a subsequent gradual growth. We didn't find nonlinear relationships between NO2 and PM10 concentrations and incident nephritis. Thus, exposure to air pollution may induce the incidence of nephritis, emphasizing the importance of controlling ambient air pollution for its prevention.</p>
9 Authors
- Qiong Duan
- Cheng Zhou
- Haifeng Chen
- Jie Zhang
- Zhaohui Ruan
- Hongfei Cao
- Zixing Zhang
- Xihai Xu
- Xinyu Fang
1 Application
| Application ID | Title |
|---|---|
| 62663 | Evaluation of causal risk factors for autoimmune diseases: evidence from epidemiological studies, phenome-wide Mendelian randomisation study |
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