| Title: | Fundus Refraction Offset as a Personalized Biomarker for 12-Year Risk of Retinal Detachment |
| Journal: | Investigative Ophthalmology & Visual Science |
| Published: | 1 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40590806/ |
| DOI: | https://doi.org/10.1167/iovs.66.9.1 |
| URL: | https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938720/i1552-5783-66-9-1_1751363130.21702.pdf |
Publication 16352
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Abstract
Purpose: The purpose of this study was to investigate the potential of a novel anatomical metric of ametropia-fundus refraction offset (FRO)-in stratifying the risk of retinal detachment (RD) or breaks, beyond the influence of risk factors including spherical equivalent refraction (SER).</p>
Methods: Participants from the UK Biobank with no prior history of RD/breaks were analyzed (n = 9320). The onset of RD/breaks over a 12-year follow-up period was determined based on linked healthcare data. A previously trained deep learning model was applied to each fundus photograph to predict SER. FRO was defined as the error in the fundus-predicted SER, with a negative value indicating a relatively myopic-looking fundus. Cox regression was used to examine the association of baseline FRO with RD/breaks-adjusting for baseline SER, baseline age, sex, and cataract surgery during follow-up. In a subgroup of participants (n = 7127) with high-quality optical coherence tomography scans, we additionally adjusted for baseline macular thickness (MT). All analyses initially considered any RD/breaks as the event, followed by rhegmatogenous RD/breaks.</p>
Results: The mean (SD) baseline age was 54.8 (8.2) years. Sixty-four participants developed RD/breaks (of any subcategory), with a mean (SD) of 7.0 (3.3) years between baseline and disease onset. A more negative baseline FRO was independently associated with an increased risk of any RD/breaks (adjusted hazard ratio [HR] = 0.66, 95% confidence interval [CI] = 0.50-0.87, P = 0.003) and rhegmatogenous RD/breaks (HR = 0.61, 95% CI = 0.45-0.82, P = 0.001). Similar independent associations were evident in the subgroup analysis that additionally adjusted for MT.</p>
Conclusions: A more negative baseline FRO is associated with a higher risk of developing RD/breaks, even among individuals with similar baseline SER and other risk factors. This demonstrates a potential benefit of shifting towards an anatomic definition of myopia.</p>
15 Keywords
- Adult
- Aged
- Biomarkers
- Female
- Follow-Up Studies
- Fundus Oculi
- Humans
- Male
- Middle Aged
- Refraction, Ocular
- Retinal Detachment
- Risk Assessment
- Risk Factors
- Tomography, Optical Coherence
- United Kingdom
5 Authors
- Fabian Yii
- Ian J. C. MacCormick
- Niall Strang
- Miguel O. Bernabeu
- Tom MacGillivray
1 Application
| Application ID | Title |
|---|---|
| 90655 | Investigating retinal features and other health characteristics that are predictive of refractive error and risk of pathologic myopia. |
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