| Title: | Relationships of Cognitive Function With Subsequent Device-Measured Physical Activity and Sedentary Time in Healthy Individuals and Those With Bipolar Disorder: Findings From the UK Biobank |
| Journal: | Acta Psychiatrica Scandinavica |
| Published: | 3 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40611430/ |
| DOI: | https://doi.org/10.1111/acps.70011 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.70011 |
Publication 16338
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Abstract
BACKGROUND: In bipolar disorder (BD), physical inactivity and sedentary behaviour are prevalent and have been linked to BD's cognitive symptoms, although the directionality of these links is not clear. This proof-of-concept study examined whether cognitive function during mid- and later-life was prospectively related to physical activity and sedentary time, and whether the association differed in presence or extent between those with BD and healthy controls.</p>
METHODS: Relevant UK Biobank data were available for 646 BD participants and 18,041 psychiatrically healthy controls, aged 40-69 years at baseline. Cognition was assessed during a baseline assessment, and wrist-worn accelerometry data were collected at a follow-up assessment 2.8-6.6 years later. Regression analyses examined prospective relationships of global cognition, diagnostic group, and their interaction, with physical activity (total, light, and moderate to vigorous) and sedentary time.</p>
RESULTS: Baseline cognitive function was inversely associated with light physical activity (coeff. = -5.64, 95% CI: -6.30 to -4.98) and positively associated with sedentary time (coeff. = 5.17, 95% CI: 4.48-5.86) and moderate-to-vigorous physical activity (coeff. = 0.48, 95% CI: 0.28-0.68) at follow-up. Observed effect sizes were small but significant. In general, associations were not moderated by age or diagnostic group.</p>
CONCLUSIONS: The current study provides preliminary evidence that cognitive function may influence subsequent physical activity and sedentary time similarly in those with BD and healthy controls; however, further research is needed to confirm and further explore this findings.</p>
9 Authors
- Elysha Ringin
- David W. Dunstan
- Denny Meyer
- Roger S. McIntyre
- Neville Owen
- Michael Berk
- Susan L. Rossell
- Mats Hallgren
- Tamsyn E. Van Rheenen
1 Application
| Application ID | Title |
|---|---|
| 60698 | Healthy Brain Aging: Normative models of brain structure, function and connectivity across the adult lifespan |
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