| Title: | Dietary Habits, Residential Air Pollution, and Chronic Obstructive Pulmonary Disease |
| Journal: | Nutrients |
| Published: | 18 Jun 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40573139/ |
| DOI: | https://doi.org/10.3390/nu17122029 |
| URL: | https://www.mdpi.com/2072-6643/17/12/2029/pdf?version=1750245405 |
Publication 16286
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Abstract
Background: The role of dietary patterns in the development of chronic obstructive pulmonary disease (COPD), particularly under varying levels of ambient air pollution, remains insufficiently understood. Aims: We aimed to investigate the association between adherence to multiple established dietary patterns and the risk of incident COPD, and to assess potential effect modification by exposure to ambient air pollutants. Methods: We conducted a prospective study including 206,463 participants from the UK Biobank free of COPD at baseline. Individual-level residential air pollution exposure was estimated for the year 2010. Nine dietary indices were derived from 24 h dietary recalls. Associations with incident COPD were assessed using Cox proportional hazards models. Effect modification was examined using smoking-specific tertiles of nitrogen oxides (NO, NO2, and NOx) and particulate matter (PM2.5, PM2.5-10, and PM10). Results: Greater adherence to healthy dietary patterns was associated with a 14% to 34% reduced risk of COPD (highest vs. lowest quintile). In contrast, high adherence to the Unhealthful plant-based diet index (PDI) was associated with a 34% increased risk (HR = 1.34, 95% CI: 1.16-1.54). Notably, the protective associations of the AHA, EAT-Lancet, and MIND dietary patterns were most pronounced in settings with relatively high air pollution, as evidenced by elevated levels in at least four air quality indicators (p for interaction < 0.05). Conclusions: Adherence to AHA, EAT-Lancet, and MIND dietary patterns is associated with a reduced risk of incident COPD, with potentially amplified benefits observed in areas with higher ambient air pollution.</p>
18 Keywords
- Aged
- Air Pollutants
- Air Pollution
- Diet
- Diet, Healthy
- Environmental Exposure
- Feeding Behavior
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Particulate Matter
- Proportional Hazards Models
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
- Risk Factors
- United Kingdom
6 Authors
- Dong Liu
- Junyi Ma
- Xia-Lin Cui
- Yunnan Zhang
- Tong Liu
- Li-Hua Chen
1 Application
| Application ID | Title |
|---|---|
| 62811 | Lifestyle, metabolic/inflammatory profile, genetics and neurological diseases among participants in the UK Biobank |
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